Pair Name	Irigenin, TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP8	hsa841
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	CFLAR	hsa8837
	Up-regulation	Expression	FADD	hsa8772
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	TNFRSF10B	hsa8795
In Vitro Model	NCI-N87	Gastric tubular adenocarcinoma	Homo sapiens (Human)	CVCL_1603
	SGC-7901	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0520
	BGC-823	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_3360
	MGC-803	Gastric mucinous adenocarcinoma	Homo sapiens (Human)	CVCL_5334
	MKN28	Gastric tubular adenocarcinoma	Homo sapiens (Human)	CVCL_1416
Result	Our present study gave new insights into the effects of Iri on potentiating TRAIL-sensitivity, and suggested that Iri could be a potential candidate for sensitizer of TRAIL-resistant cancer cell treatment.